Nestled on the 2nd floor of the Neonopolis Complex in vibrant Downtown Las Vegas, this dystopian, futuristic entertainment destination promises unrivaled sensory experiences! SUBSTANCE is centrally located in the heart of Downtown Las Vegas, on the second floor of the Neonopolis entertainment complex at 450 Fremont St. Enter the complex from any direction and take either the escalators or elevator to the second floor, and follow the signs.